A depleted Coldstream team missing no fewer than six players were always up against it away to the East of Scotland League champions.
Kevin Keane, Sean Wringe, a Willis Hare penalty and Ryan Malcolm found the net for the home side, with John Crawford netting for Coldstream in reply.
There were so many players missing for a variety of reasons that the Streamers were only able to name one substitute.
Teenage midfielder Regan Graham was handed his first start and Jake Rutherford also started for the first time since re-joining the club in the summer.
Despite the final scoreline, manager Neil Oliver will be satisfied with the performance from his makeshift team in the circumstances.
The visitors were 1-0 down at half time, and even when Lothian doubled their lead Coldstream made life difficult for the Edinburgh side and continued to create chances of their own.
Striker Jack Hay had the best of them, side-footing past the post with only the goalkeeper to beat.
Coldstream goalkeeper Mark Walters pulled off a couple of outstanding saves, but and game was effectively over when Lothian scored their third from the penalty spot.
John Crawford pulled one back for Coldstream to give them faint hopes of a comeback.
But Lothian recovered from that brief setback to finish as the stronger team and score a fourth goal late on.
Coldstream: M Walters, G Wales, R Baxendale, G Hay, M Allan, J Hebdon, J Rutherford (D Powling), R Graham, J Crawford, J Hay, J Lauder.